In 2012, excitement rippled through the scientific community with the discovery of an enzyme that appeared to be, just maybe, a powerful new tool for combating Alzheimer’s. At the Mayo Clinic in Florida researchers identified a gene, BACE2, which appeared to destroy beta-amyloid — a protein, then understood to be toxic, which is found in clusters in the brains of people living with Alzheimer’s. Alzheimer's is often diagnosed by measuring the amount of buildup of this protein. A large amount of it is an indicator of the disease. People with this buildup often do not have enough of the BACE2 enzyme created naturally in their body. If a way to synthesize this enzyme artificially or to prompt the body to create more were discovered, it could be hailed as a cure for Alzheimer's. How does the BACE2 enzyme work?

Answers

Answer 1

Answer:

BACE2 cuts both beta-amyloid and beta-amyloid precursor protein.

Explanation:

What makes BACE2 so effective in fighting Alzheimer's is its efficiency in cutting both beta-amyloid and the protein that develops it. There are other enzymes, which have the ability to break down beta-amyloid, but BACE2 is the only one that breaks it down into such small pieces that it completely destroys it. Furthermore, BACE2 is able to break down the beta-amyloid precursor protein, which prevents the formation of beta-amyloid from taking place.


Related Questions

Observe an ecosystem in your locality, name the ecosystem, list all the biotic and abiotic components of the ecosystem, and make a diagram to represent the interaction of the components.

Answers

Answer:

Ecosystem: Native ForestBiotic components: trees, shrubs, herbs, grasses, fungi, lichens, rodents, foxes, puma, small birds,  owls, birds of prey, amphibians, reptiles, snakes, insects, microorganisms.   Abiotic components: Sunlight, dead organic matter, river, stones, rocks, fertile soil, nutrients.

Explanation:

Ecosystems include all the biotic, physical, and chemical components of nature, continuously interacting and depending on each other. The ecosystem is composed of living beings and non-living things that interact and depend on each other. These are the biotic and abiotic factors.  

A few examples of abiotic factors are solar light, minerals, water, air, gases, soil, and humidity.

Examples of biotic factors are plants, animals, insects, microorganisms, etc.

An example of an ecosystem in my locality is the native forest in the hills.

The forest is composed of many vegetable species, among which we may find trees, shrubs, herbs, grasses. We can also find lichens and fungi. Many mammal species such as little rodents, foxes, puma. Many bird species, among which we can find owls and some other birds of prey. There are different kinds of snakes and reptiles. There are amphibian species near the shore of the river that is crossing the forest. The soil is quite fertile, providing nutrients to the organisms. There is too much organic matter of vegetable origin, such as leaves or fallen and dead trees. Many microorganisms live in this dead matter. Insects are everywhere. There are some steep slopes in which stones, rocks, and tree roots hold the ground.

Ecosystem: Native ForestBiotic components: trees, shrubs, herbs, grasses, fungi, lichens, rodents, foxes, puma, small birds,  owls, birds of prey, amphibians, reptiles, snakes, insects, microorganisms.Abiotic components: Sunlight, dead organic matter, river, stones, rocks, fertile soil, nutrients.

List the 7 levels of classification from largest to smallest.
A. Kingdom, Phylum, Order, Class, Family, Genus, Species

B. Kingdom, Phylum, Order, Family, Class, Genus, Species

C. Phylum, Kingdom, Order, Family, Class, Genus, Species

D. Kingdom, Phylum, Class, Order, Family, Genus, Species

Answers

Answer:

List the 7 levels of classification from largest to smallest.

D. Kingdom, Phylum, Class, Order, Family, Genus, Species

Answer:

D. Kingdom, Phylum, Class, Order, Family, Genus, Species

Explanation:

These are the 7 levels of classification from largest to smallest.

___ has a definite shape and do not easily take shape of their container

Answers

Answer:

solid has a definite shape and do not easily take shape of their container

the answer is solids

hi pls help me im struggling with this question for a while i would really apreciate it

Answers

Answer:

Allopatric speciation

Explanation:

Where a population forms new species due to geographical barrier

That has separated the initial original population into 2 separate population which cannot interbreed

Each Taxonomy (category) gets less and less specific as they go further down the list.

A. True

B. False

Answers

Answer:

B. False

Explanation:

The levels of classification, from broadest to most specific, include: kingdom, phylum, class, order, family, genus, and species.

Answer:

B. False

Explanation:

Taxonomy is the study of the general principles of scientific classification.

Why don't whales have saliva?
______
Kinda curious to know! :3​

Answers

The seawater dilute the saliva in them, so the necessary digestive enzymes they can't use.

This elasticity helps cetaceans to renew 90% of the air in their lungs in a single breath. The gene SLC4A9 is partly responsible for the production of saliva in terrestrial mammals, but your average dolphin or whale has little need of spittle which is why it has been lost in cetaceans.

how do mutations lead to variations?​

Answers

A mutation is a change in a genetic sequence. Mutations include changes as small as the substitution of a single DNA building block, or nucleotide base, with another nucleotide base. ... Mutations can introduce new alleles into a population of organisms and increase the population's genetic variation.

Answer:

by producing changes in the genetic code

Explanation:

PLATO

NO LINKS PLEAE

The physical environment and environmental conditions in a biome determine, to a large degree, which living organisms are found there.


O A. true

O B. false

Answers

TRUE I THINK I DID THIS BEFORE

The most important feature that permits a gene to act as a molecular clock is The most important feature that permits a gene to act as a molecular clock is having a reliable average rate of mutation. having a larger proportion of exonic DNA than of intronic DNA. its being acted upon by natural selection. having a large number of base pairs. its recent origin by a gene duplication event

Answers

Answer:

The answer is "The first choice".

Explanation:

The hypothesis of such a molecular clock says because DNA and protein sequences develop at a pace generally constant over time as well as between different organisms. The whole idea is thus incredibly beneficial and for estimation of the historical periods, if the molecular biological hypothesis is valid, then the most significant feature enabling DNA to act as a molecular clock it has a reliable mean mutation.

which would have most likely stopped Mendel from finding a pattern in his results

Answers

The options attached to the given question is attached here as well as in the comments of the question:

A.If having a wrinkled seed had been a recessive trait

B.If garden peas reproduced more quickly

C.If seed shape did not have a clearly dominant form

D.If having a smooth seed had been a dominant trait

Answer:

The correct answer is - C. If the seed shape did not have a clearly dominant form.

Explanation:

Mendel studied and perform his research on seven different traits in peas, which are – height, seed color, flower color, and seed shape. In Mendel’s study, every trait has traits that are clearly either dominant or recessive.

Similarly, the seed shape has a very clear dominant form which is smooth seed dominant over wrinkled seed that is a recessive trait. If this clear dominant form or recessive form could not be established, then Mendel’s experiment would have most likely stopped its progress.

SCIENCE
Which of the following is an example of a glacial formation?
A. Photosynthesis
B. Methane degradation
C. Photolysis
D. Weathering of rocks

Answers

The answer for this question is A

Answer:

Letter D is the Correct answers

Explanation:

base on my research

What is the receptors?

Answers

Answer:

In biochemistry and pharmacology, receptors are chemical structures, composed of protein, that receive and transduce signals that may be integrated into biological systems

During a race the leg muscles of an athlete use more energy than can be supplied by aerobic respirationWhich substance will build up in the leg muscles and cause pain?A. Carbon dioxide B. Ethanol C. Lactic acid D. Water

Answers

Answer:

C. Lactic Acid

Explanation:

Which of the following accurately describe characteristics of the cell membrane. Choose all that apply. *

Impermeable
Made of many moving molecules
Monolayer of lipids
Rigid and unchanging
Selectively permeable

Answers

Answer:

selectively permeable

A climax community is reached
A. at the beginning of succession.
C. at the end of succession.
B. in the middle of succession.
D. when an ecosystem is destroyed.

Answers

Answer:

C is the right one.........

In a food chain and web, only 10% of the energy produced by a level in a food chain is passed on to its predator so there has to be many more “prey” than “predators”. If 2000 kcal of energy are available in grass, how much energy would be available to the cow that eats the grass? How about to the human that eats the cow?

Answers

Answer:

If only 10% of energy is passed down the cow would only get 200 kcal of energy from the grass. The human would get 10% less than that which is only 20 kcal of energy from the cow.

Explanation:

SO you hopefully selected that an Allele is a form of a gene. BUT what is this really...

A. an allele is a protein that causes hair no hair in the guinea pig

B. an allele is a length of DNA with a specific sequence of nitrogen bases that make a protein that results in Hair or No Hair on the guinea pig

Answers

Answer:

B. an allele is a length of DNA with a specific sequence of nitrogen bases that make a protein that results in Hair or No Hair on the guinea pig

Explanation:

An organism that has two different alleles of the gene is called heterozygous. Phenotypes (the expressed characteristics) associated with a certain allele can sometimes be dominant or recessive, but often they are neither.

B. an allele is a length of DNA with a specific sequence of nitrogen bases that make a protein that results in Hair or No Hair on the guinea pig

PLS HELP NOW dont have to answer all

Answers

Answer: For Question 6; False

Explanation: No, the arrow points to what eats that particular animal.

Answer:

6. false.

9. because of heat given off, only 10% of the energy is going to go to each level .

Organelles are specialized structures that perform important cellular functions; they are structures you can generally see only under a microscrope. Which of the organelles below would you expect to find in all living cells?
A) cell membrane
B) cell wall
C) DNA
D) Cytoplasm
E) Nucleus
F) Chloroplasts

Answers

Answer:

I think D which is the cytoplasm

Explanation:

because it is not specific with cell is this off so cytoplasm is there in both the animal cell and plant cell

Part B:
Which BEST describes the result of this mutation?
A
The entire sequence of amino acids is changed.
B
The RNA strand does not code for the correct amino acids.
С
The change in amino acids shortens the polypeptide sequence.
D
The alternation of a single nucleotide encodes for a different amino acid.

Answers

Answer:

A . The entire sequence of amino acids is changed.

Explanation:

The entire sequence of amino acids is changed when the mutation occurs in the protein because amino acid is the building block from which protein is made. Mutation is the sudden change that is occur in the genetic makeup i.e. DNA when the cell is exposed to radioactive radiation of chemicals. So due to this change, the sequence of amino acids changed and they work differently.

Mr. and Mrs. Green have a daughter, Georgia, who was born at Riverside Community Hospital. Mr. and Mrs. Blue have a daughter, Belle, who was born on the same date at the same hospital. Mrs. Green, having recently seen Belle, is convinced that Belle and Georgia had been assigned to the wrong parents at the hospital. Mrs. Green thinks that Belle is her biological daughter. ABO blood analysis was performed on all individuals involved:Mr. Green: Type AMrs. Green: Type A Georgia: Type AMr. Blue: Type ABMrs. Blue: Type ABelle: Type O
Is Mrs. Green correct? Is Belle her biological daughter? Explain.

Answers

Answer:

Yes, Mrs Green is correct that Belle is her biological daughter

Explanation:

According to this question, Mr. and Mrs. Green is said to have a daughter, Georgia while Mr. and Mrs. Blue is said to have a daughter, Belle. Both daughters were born the same day. Hence, a controversy occured as Mrs. Green thinks that Belle is her biological daughter.

Based on the blood analysis, the following were obtained:

Mr. Green: Type A

Mrs. Green: Type A

Georgia: Type A

Mr. Blue: Type AB

Mrs. Blue: Type A

Belle: Type O

The genotype of the following blood types is as follows:

Type A - iAiA or iAi

Type B - iBiB or iBi

Type O - ii

Type AB - iAiB

From the analysis of blood types of Mr and Mrs Green, which are both type A, they can possibly produce a child with type A.

However, from the analysis of Mr. and Mrs. Blue, it is impossible to have a child with blood type O. However it is possible for Mr and Mrs. Green if they are both heterozygous (iAi × iAi). The punnet square is attached. Hence, Mrs Green is correct about her claim since Mr. and Mrs. Blue cannot have a child with blood type A.

Which property of nervous tissue is fundamental to its function of coordinating the body's activities?
A.)cells that are tightly packed
B.)contains extracellular matrix
C.)presence of neurons
D.)short life span

Answers

Answer:

i think the awnser is a

Explanation:

Answer:

C

Explanation:

he wrong

Asha went to visit her grandfather in the village .She found that he was worried about the productivity level of crops for that year. Asha suggested a naturalmethod and asked him to plant crops like pulses, gram and beans for a year and then follow with regular crops.A)What will you name the process suggested by her?B)What could be the reason for the decrease in crop productivity? C)What are the benefits of this process?

Answers

Answer:

Crop rotation.

Explanation:

Crop rotation is the method by which regular crops are cultivated after leguminous crops. Leguminous crop have nodules in their roots that has bacteria which fixes nitrogen for the plant which means that the plant produce their own fertilizer which can be used by the plant as well as a lot of nitrogen is also present for the other crop which increases productivity of the regular crops. The unavailability of nutrients is the main reason for the decrease of productivity. The main benefits of this method is increase productivity and nutrient level in the soil.

How is gene cloning helpful in biological research??

Answers

Answer:

Biologists frequently utilize DNA cloning in basic research labs to create fake, recombinant versions of genes to better understand how normal genes in an organism function.

Explanation:

Took the lesson on Khan Acdemdy, its from my notes i took

Why can't you sing just like Elvis Presley?

A. Because your DNA is exactly like his

B. Because your DNA mutated from his

C. Because your DNA is slightly different from Elvis's DNA

Answers

Answer:

it's C

Explanation:

lol I think C tbh…….

The outcome of protein synthesis is ______.
A. A glucose molecule

B. An mRNA molecule

C. A protein

Answers

Answer:

C. A protein

Explanation:

The outcome of protein synthesis is a protein.

The process of protein synthesis is crucial to cellular function. Protein synthesis is the procedure used by cells to generate proteins. Thus, option C is correct.

What is the role of protein synthesis in the cell?

Protein synthesis, sometimes referred to as protein biosynthesis, is an essential biological process that occurs inside of cells to replace lost proteins (due to export or degradation) with new proteins.

Proteins have a wide range of vital biological functions, including those as enzymes, hormones, and structural proteins.

Cells are made of proteins, and the word “synthesis” simply means “to make.” Thus, the process of producing proteins is known as protein synthesis.

Creating a polypeptide, or protein consisting of a chain of amino acids, is the sole goal of protein synthesis. Keratin, a protein, is produced in the cells of the hair follicle.

Therefore, The outcome of protein synthesis is a protein.

Learn more about protein here:

https://brainly.com/question/18800216

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write a short story on the journey of a sperm cell seeking to enter in a egg cell to share life together as a zygote and beyond​

Answers

(See the attached picture)

Direction: Write a short story on the journey of a sperm cell seeking to enter in a egg cell to share life together as a zygote and beyond.

Answer:

The goal of the sperms’ journey to the egg is to fertilize it. To do so, the sperm cell must pass through a long and challenging path. This is one of the reasons why the total number of motile sperm cells is very important, and a key parameter for a man’s potential to reach pregnancy with his partner.

The sperms’ journey to the egg begins with millions of sperm cells that are released into the female reproductive tract during intercourse. The sperm cells gain their full ability to swim when they are ejaculated into the reproductive tract.

Upon ejaculation, the sperm cells are enclosed in a fluid called seminal plasma or semen, which is a mix of fluids from the testes, seminal vesicles, prostate, and the bulbourethral glands. The fluid contains elements which protect the sperm cells during their journey towards the egg. The semen thickens and helps the sperm cells stay inside the woman – as close as possible to the cervix, which is the “gate” to the egg.

Liquid extends from the cervix, allowing the sperm cells from the semen to swim into the cervix. Only the strongest sperm cells will make it this far. Once through the cervix, the sperm cells swim across the uterus and into the fallopian tubes.

I hope it helps!!

The sperm cell fertilizes the egg and forms a zygote, which is further divided into multiple cells and becomes a child. The division is the process of mitosis that takes place from the zygote to the child's development.

How is the zygote formed and developed?

The sperm and the ovum are produced by the process of meiosis from the male and female, respectively, and when both fertilize, the zygote is formed. The fertilized zygote is a single cell, but later that cell is further divided mitotically and forms a morula, then a blastula, and then the gastrula.

The cells of the gastrula undergo cell differentiation, different organs are developed, and the baby is finally formed. The child then continues to grow in size, and different organs grow and form the mature organ system. After a certain age, the reproductive organs start to mature and are capable of forming the gametes.

Hence, all of these events occurred from the zygote to the child's maturity.

Learn more about the zygote here.

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Kingdoms are a more specific (less broad) category in the taxonomic hierarchy.

A. True

B. False

Answers

Answer:

a

Explanation:

According to the taxonomical hierarchy, the kingdom is the highest category in biological classification. It is a group of closely related organisms.  

Kingdom - Phylum -Class - Order -Family - Genus -Species.

Answer:

A. True

Explanation:

Yes, Kingdoms are a more specific (less broad) category in the taxonomic hierarchy.

2. What has happened to the level of carbon dioxide in the atmosphere in the past several
decades (use numbers and units)?

Answers

Answer:

Nov 23, 2020 · Levels of carbon dioxide (CO2) in the atmosphere hit a new record of 410.5 parts per million in 2019, and are expected to keep rising this year, the World Meteorological Organization (WMO) said in its annual Greenhouse Gas Bulletin on Monday. “We breached the global threshold of 400 parts per million in 2015.

Explanation:

i dont know this is the correct answer???/

While heating a solution in a beaker, what is the appropriate safety equipment
to have on the bench?
A. Thermal gloves
B. Fire extinguisher
C. Latex gloves
D. Fire blanket

Answers

Answer: A

Explanation: Hope it helps

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